The AIDS response needs a people-centred investment approach so that returns are maximized. For the response, the returns are clear - zero new infections, zero discrimination and zero AIDS-related deaths. AIDS-related investments must be smart and produce results for people; results that matter – lives saved, keeping people from acquiring HIV infection, keeping people alive and keeping people and families healthy and productive.

Key elements of HIV responses fall in three categories – “basic programme activities”, “critical enablers” and “synergies with development sectors” – to help countries and implementation partners focus and prioritize their efforts.